Effect and underlying mechanism of morin on the pharmacokinetics of diclofenac sodium in rats

1. Morin, a natural flavonol, is present in many plants. It has anti-inflammatory and immunomodulatory activities often used as an adjuvant treatment for arthritis. Diclofenac sodium the first-choice drug of rheumatoid However, herb-drug interaction (HDI) between morin diclofenac remains unclear.2. The aim research was to investigate whether how affect pharmacokinetic profile sodium.3. enzyme kinetic studies showed that significantly accelerated metabolism reduced systemic exposure sodium. Interestingly, effect on not dose-dependent manner. Therefore, P-glycoprotein (P-gp) further investigated.4. results implied influence mechanism might be related CYP2C9 P-gp. Attention should paid risk HDI clinical practice.